Monthly Archives: July 2020

The dawn of Pharmaco-Genetics for AMD – Page 37 of 57

Case 3: Annidis MSI Infrared3 OS The pigmentary changes in both eyes suggests dry AMD. Some of the pigmentary changes in OS may be due to the central serous. CSCR does increase the risk (to some extent) and the patient was offered and then desired genetic testing with its predictive abilities.

The dawn of Pharmaco-Genetics for AMD – Page 37 of 572023-01-31T21:30:14+00:00

The dawn of Pharmaco-Genetics for AMD – Page 34 of 57

Case 3: Annidis MSI OS In his left eye, pigmentary clumping — really pigmentary atrophy, hypertrophy and migration — is more obvious. This is the eye with a history of CSCR which was never fully resolved.

The dawn of Pharmaco-Genetics for AMD – Page 34 of 572023-01-31T21:30:15+00:00

The dawn of Pharmaco-Genetics for AMD – Page 31 of 57

Case3: Annidis MSI OD A 61 yo white male presents for his 6 month follow-up. He has a documented history of central serous chorioretinopathy (CSCR) in left eye. VA cc is 20/20 OD and 20/20- OS. Home amsler grid reveals no change in either eye but the same subtle distortion when viewing with his

The dawn of Pharmaco-Genetics for AMD – Page 31 of 572023-01-31T21:30:15+00:00

The dawn of Pharmaco-Genetics for AMD – Page 30 of 57

Findings from Landmark Study1 Three of the nine graphs in Figure 1 of the landmark study have been selected and slightly modified for this brief discussion. In the graph on the left, the patient has zero high risk CFH alleles but 2 ARMS2 high risk alleles. The lowest rate of progression here corresponds to

The dawn of Pharmaco-Genetics for AMD – Page 30 of 572023-01-31T21:30:16+00:00

The dawn of Pharmaco-Genetics for AMD – Page 29 of 57

Key AMD genes Macula Risk NXG includes 15 variants across 12 genes that represent all of the key biological pathways that have been associated and validated with AMD. This is the most comprehensive genetic test available. The CFH and ARMS2 alleles are most important in determining which supplement a specific patient should be consuming.

The dawn of Pharmaco-Genetics for AMD – Page 29 of 572023-01-31T21:30:16+00:00

The dawn of Pharmaco-Genetics for AMD – Page 28 of 57

The Macula Risk score Macula Risk predictions are expressed as a risk score that is compared with the risk for the average person. There are many genetic and other factors that contribute to the prediction of AMD progression. Five risk levels (ranges) are defined using Macula Risk testing. Risk levels 3, 4 and 5

The dawn of Pharmaco-Genetics for AMD – Page 28 of 572023-01-31T21:30:16+00:00