Case #65 – Subretinal Drusenoid Deposits (SDDs) in AMD – Page 8 of 66

Risk Factors in Development of SDDs

• Increasing age⁵
• Late AMD
  • The likelihood of SDD presence increases with AMD severity, more likely present in GA > CNV > intermediate AMD > early AMD¹
• Possible genetic predisposition
  • Specifically risk alleles in Complement Factor H (CFH) and Age-Related Maculopathy Susceptibility 2 (ARMS2)⁹
• Significantly prolonged dark adaptation, even in the setting of a clinically benign appearing macula³
• Highest rate of occurrence is in a diagnosis of AMD¹¹, but SDDs can be associated with other retina conditions including:
  • Sorsby macular dystrophy¹²
  • Adult-onset vitelliform dystrophy¹²
  • Pseudoxanthoma elasticum¹³
  • Fundus albipunctatus¹⁴