Pathophysiology:

  • Develop from unregulated proliferation of uveal melanocytes
  • Five genes most commonly implicated: GNAQ, GNA11, BAP1, SF3B1, EIF1AX
  • Ciliary body melanomas usually remain hidden behind the iris diaphragm and are undetected for a longer period of time than melanoma in the iris or choroid

Note: significant sentinel episcleral vessel nasal