Case #68: MEK-Inhibitor Associated Retinopathy (MEKAR) – Page 8 of 18

MEKAR (MEK Inhibitor Associated Retinopathy)

• Multifocal yellow-grey elevations of the fundus (typically circular, without inferior fluid tracking)

  See: https://www.retinarevealed.com/case-64-gravitational-tracks-in-bilateral-central-serous-chorioretinopathy-page-1-of-20/

• Typically bilateral, can be unilateral (rare)
• ~50% of patients may be symptomatic with vision loss no more than 2 Snellen lines of acuity from baseline (and returns to within 1 line of baseline after fluid resolution)
• OCT characteristics: fluid accumulation between RPE and IZ in various configurations (see next slide)
• MEK Inhibitor does not need to be stopped for fluid to resolve