Case #74: Pentosan Polysulfate Maculopathy: Another Differential Diagnosis for Night Blindness – Page 17 of 23

Proposed Disease Severity Stages^5,8

Wang and colleagues

Mild: Speckled pattern on FAF without well-demarcated atrophic lesions on FAF and no evidence of complete RPE and outer retinal atrophy

Moderate: Well-demarcated, nummular, and localized lesions with RPE and outer retinal atrophy; no central foveal involvement

Severe: Well-demarcated lesions with associated hypoAF atrophy with RPE and outer retinal atrophy, which involves the central fovea