Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 21 of 31
MRI Brain Anatomy
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 20 of 31
Histological Section as Compared to the OCT Image Although the photoreceptor integrity line, or the PIL (defined as the junction between the inner and outer segments) is barely visible in most histological sections, it is highly prominent in normal SD OCTs. The PIL, as shown above, should be continuous throughout the entire scan in normal
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 19 of 31
mfERGs in a normal subject mfERGs responses in our 49 year old male patient The top left image demonstrates the actual mfERG in one specific normal subject. The bottom left image compares these results to the normative database. The central hill in the top left image from a normal
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 18 of 31
Introduction to mfERGs The typical stimulus for multifocal electroretinogram (mfERG) is shown in the left image above. Usually, 103 hexagons pattern reverse from white to black and black to white in a pseudo-random sequence. The resultant response from the retina is a topographically accurate ERG from 103 different locations. The total field
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 17 of 31
Optovue Full Retinal Thickness The vertical section of the retina OS and OD through the fovea above are reduced thickness both inferiorly and superiorly when compared to the normative database.
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 16 of 31
Optovue Outer Retinal Thickness The vertical section of the retina OS and OD through the fovea above demonstrate reduced thickness of the outer retina both inferiorly and superiorly when compared to the normative database.
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 15 of 31
Optovue GCC Thickness-OS
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Optovue GCC Thickness-OD
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 13 of 31
Significance Map ExplanationA Significance Map is provided that shows the regions on the Deviation Map where the percent loss is statistically significant. The Significance Map shows normal areas as green, borderline areas as yellow, and outside normal areas as red (see figure below). These are based on probability values of p < 5% for borderline
Non-glaucomatous RNFL loss with Cerebellar Atrophy – Page 12 of 31
GCC Map Comparison The GCC map for a normal eye shows a bright circular band surrounding the macula representing a thick GCC from healthy ganglion cells (fIgure A). The center of the macula is thinner because there are no ganglion cells in this area. In glaucoma, as the ganglion cells are lost, the GCC