Case #2 – Plaquenil Induced Retinal Toxicity

Plaquenil Induced Retinal Toxicity – Page 6 of 25

optomap® images to the left demonstrate the widespread far peripheral defects in both color images and in optomap® FA images. These somewhat non-specific findings may be secondary to an unrelated disorder such as peripheral neurosensory degeneration or perhaps secondary to the Plaquenil toxicity. (A cursory search of the world's Plaquenil

Plaquenil Induced Retinal Toxicity – Page 6 of 252020-06-12T20:00:23+00:00

Plaquenil Induced Retinal Toxicity – Page 5 of 25

Red Laser Separation Green Laser Separation optomap® Images OU are normal as shown in the individual laser separations [Red laser separations are the images to the left; green laser separations are the images to the right]. Separation of the composite optomap® images into red and green laser channels is

Plaquenil Induced Retinal Toxicity – Page 5 of 252020-06-16T17:34:22+00:00

Plaquenil Induced Retinal Toxicity – Page 4 of 25

optomap® color fundus image OS as contrasted to optomap® FA OS. The color (composite) image appears normal in the macula in contrast to the obvious Bull’s Eye lesion with FA. Slack Panoramic Ophthalmoscopy Book @ slackbooks.com

Plaquenil Induced Retinal Toxicity – Page 4 of 252020-10-21T08:24:09+00:00

Plaquenil Induced Retinal Toxicity – Page 3 of 25

optomap® color fundus image OD as contrasted to optomap® FA OD. The color (composite) image appears normal in contrast to the obvious Bull’s Eye lesion with FA. Slack Panoramic Ophthalmoscopy Book @slackbooks.com Note: Arrows denote shadows cast by large vitreal floaters which change position from image to image.

Plaquenil Induced Retinal Toxicity – Page 3 of 252020-10-21T08:24:01+00:00

Plaquenil Induced Retinal Toxicity – Page 2 of 25

History/Chief Complaint 50 year old female presented with deteriorating vision over the past several years. She reported using Plaquenil 200 mg BID over a 9 year period for SLE. The drug was discontinued two years earlier, when vision loss was initially documented. Clinical Findings BCVA: OD 20/40 and OS 20/200 -2 years earlier, when

Plaquenil Induced Retinal Toxicity – Page 2 of 252020-06-12T19:55:27+00:00

Plaquenil Induced Retinal Toxicity – Page 0 of 25

Although the vast majority of patients on long term Plaquenil theraphy never develop vision loss, eye clinicians (as well as the prescribing rheumatologists and the patients themselves) remain concerned about the small number who do since severe and irreversible vision loss occasionally results.As documented in the case and discussion that follow, several advanced diagnostic technologies

Plaquenil Induced Retinal Toxicity – Page 0 of 252020-06-01T12:43:21+00:00