Case #23 – Congenital Hypertrophy of the RPE

Congenital Hypertrophy of the RPE – Page 44 of 44

References Ahn ES, Singh AD. Isolated Anomaly of the Retinal Pigment Epithelium. Ocular Oncology Cases from Cole 2010; 29-30. Coleman P, Bernard NAS. Congenital hypertrophy of the retinal pigment epithelium: prevalence and ocular features in the optometric population. Ophthal Physiol Opt 2007; 27:547-555. Regillo CD, Eagle RC, Shields JA, Shields CL, Arbizo W. Histopathologic

Congenital Hypertrophy of the RPE – Page 44 of 442021-01-05T21:52:31+00:00

Congenital Hypertrophy of the RPE – Page 42 of 44

Douglas C. Anderson Douglas Anderson, Founder and Vice President of Optos® developed the optomap® in 1992 after his then five-year-old son went blind in one eye as a result of a retinal detachment being detected too late. Mr. Anderson has extensive experience in the management of the product development process and building early

Congenital Hypertrophy of the RPE – Page 42 of 442021-01-05T21:53:19+00:00

Congenital Hypertrophy of the RPE – Page 41 of 44

Jerome Sherman, OD, FAAO Jerome Sherman, O.D., is perhaps optometry's most prolific writer, publishing over 650 clinical articles, research manuscripts, book chapters and two CDs. He is senior author of three books that were published in 2007, and has delivered over three thousand lectures both nationally and internationally. He has served as a contributing

Congenital Hypertrophy of the RPE – Page 41 of 442021-01-05T21:53:29+00:00

Congenital Hypertrophy of the RPE – Page 39 of 44

Comments and Conclusion (cont'd) CHRPE-like lesions have been given the name pigmented ocular fundus lesions (POFLs) due to their dissimilar clinical characteristics to solitary and grouped CHRPE lesions, and have been shown to be present in approximately two thirds of patients known to have FAP.1,8 Eye care specialists have used the term, Gardner's syndrome,

Congenital Hypertrophy of the RPE – Page 39 of 442021-01-05T21:53:53+00:00

Congenital Hypertrophy of the RPE – Page 38 of 44

Comments and ConclusionsCHRPE is generally described as a flat and pigmented lesion at the level of the retinal pigment epithelium (RPE) that is round and darkly pigmented, often surrounded by a halo of hypopigmentation.1 Often the lesions show scalloped edges and have areas of depigmentation within or encompassing the lesion known as lacunae.1 Patients who

Congenital Hypertrophy of the RPE – Page 38 of 442021-01-05T21:54:04+00:00

Congenital Hypertrophy of the RPE – Page 37 of 44

Case 12: Optomap® Fundus Image Comparison of Left Eye The differential diagnosis also includes inactive toxoplasmic retinitis, the black sunburst of sickle cell retinopathy, pigment proliferation following trauma, and virtually any cause of hyperplasia of the RPE, all of which show a haphazard dispersion of pigment with irregular or jagged margins, unlike CHRPE

Congenital Hypertrophy of the RPE – Page 37 of 442021-01-05T21:54:12+00:00

Congenital Hypertrophy of the RPE – Page 36 of 44

Case 12: Optomap® Fundus Image Comparison of Left Eye The three pigmented lesions are quite typical of old, inactive retinochoroiditis scars due to toxoplasmosis. In contrast, the lesion closest to the disc with hazy borders without pigment in the left image (see blue circle) is typical of an active toxoplasmosis lesion. Reactivations of

Congenital Hypertrophy of the RPE – Page 36 of 442021-01-05T21:54:20+00:00

Congenital Hypertrophy of the RPE – Page 35 of 44

Case 12: Multiple Contiguous Lesions in Retinochoroidal Inflammation Optomap® Color Fundus Images of Left Eye Case 12: A 35-year-old Hispanic female presented with complaints of increased light sensitivity in her left eye with a history of reoccurring retinal inflammation in the same eye. BCVA measured 20/20 OU. The left eye demonstrated a very hazy view

Congenital Hypertrophy of the RPE – Page 35 of 442021-01-05T21:54:28+00:00