Case #28 – Chorioretinal Lacunae

Chorioretinal Lacunae – Page 20 of 40

Case 2: Zeiss FF450plus Color Fundus Camera* Montage of Left Eye Note the multiple retinal lesions in the left eye superior temporal with the largest oval lesion in the mid-temporal periphery. * VISUPAC 481 ZK5 and Pike 145

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Chorioretinal Lacunae – Page 19 of 40

Case 2: Zeiss FF450plus Autofluorescence Fundus Camera* Image of Right Eye FAF did not reveal any gross abnormalities in the right eye. * VISUPAC 481 ZK5 and Pike 145

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Chorioretinal Lacunae – Page 18 of 40

Case 2: Zeiss FF450plus Color Fundus Camera* Montage of Right Eye Case 2: A 19-year-old Hispanic female (who is the sister of the patient in Case 1) presented for follow up for multiple retinal lesions in her left eye. BCVA measured 20/25- OU. * VISUPAC 481 ZK5 and Pike 145

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Chorioretinal Lacunae – Page 17 of 40

Case 1: Midsagittal MRI Scan Image Aicardi syndrome is characterized by chorioretinal lacunae, infantile spasms and agenesis of the corpus callosum. A midsagital MRI of our patient revealed a completely normal corpus callosum. Though our patient does not have a history of infantile spasms or an abnormal corpus callosum, Aicardi syndrome cannot

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Chorioretinal Lacunae – Page 16 of 40

Case 1: RNFL Measurement OS with Cirrus™ HD-OCT Note the RNFL was thin nasally in the OS for unexplained reasons. The RNFL measurements were normal in the right eye (not shown).

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Chorioretinal Lacunae – Page 15 of 40

Case 1: Cirrus™ HD-OCT Macula Thickness Measurements OU The thickness of the macula measured normal in both eyes. However, note most of the thickness measurements were lower in the left eye.

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Chorioretinal Lacunae – Page 13 of 40

Case 1: Cirrus™ HD-OCT Horizontal Single Line Raster Scan Images Patient vs. Normal Control OS Patient Normal Control When the patient’s OCT is compared to a normal control in the same region it is obvious that many of the retinal layers are missing.

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Chorioretinal Lacunae – Page 12 of 40

Case 1: Cirrus™ HD-OCT Horizontal 5-Line Raster Scan Images OS The retinal lesion appears slightly excavated and was previously diagnosed as a coloboma. However, retinal colobomas are typically far more deeply excavated than in this case.

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Chorioretinal Lacunae – Page 11 of 40

Case 1: Cirrus™ HD-OCT Horizontal 5-Line Raster Scan Images OS All the retinal layers appear normal before reaching the retinal lesion. As the retinal layers reach the border of the lesion several of them appear to “collapse”.  An OCT section through the lesion reveals several absent retinal layers down to

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