Case #46 – Clinical Applications of VEPs

Clinical Applications of VEPs – Page 20 of 41

Case 2: Optovue iWellness Exam Our young patient demonstrates a profound loss of the Ganglion Cell Complex (GCC). The mean thickness of normals is 95 microns with a Standard Deviation (SD) of 7.5 microns. Here the Total Thickness is about 65 microns or 4 SDs away from the mean value. In spite

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In contrast to the typical presentation, this patient has a palish disc, apparent reduction of the RNFL and no corkscrew vessels. Only a small percentage of patients with a LHON mutation present in this fashion.2

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Case 2: A 7-year-old WM with ADHD presented with BCVA 20/20-2 OD and 20/25- OS. Pupils and externals were within normal limits. Ophthalmoscopy revealed palish discs OU and patient history revealed a mother with light perception VA due to a mt4360 LHON (Leber Hereditary Optic Neuropathy) mutation. LHON is a maternally inherited mitochondrial

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Example of a different case with a poor prognosis for establishing binocularity. Each pattern reversal of a black and white, 64X64 checkerboard stimulates the normal visual system to oscillate in harmony with the stimulus frequency rate. In this case, the pattern reversal rate is 7.5 cycles/sec (just outside the alpha rhythm of the brain

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Case 1: Optovue iWellness Exam The Ganglion Cell Complex RR #21 page 29 - 31 is 87 microns in thickness in the right eye and 92 microns in the left eye. Generally, a difference of 10 or more microns is considered to be statistically significant. Note the minor asymmetry of the GCC "green

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Histological Section as Compared to the OCT Image  Although the Photoreceptor Integrity Line, or the PIL (defined as the junction between the inner and outer segments) is barely visible in most histological sections, it is highly prominent in normal SD OCTs. The PIL, as shown above, should be continuous throughout the entire scan

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