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Based upon the previous results, an MRI of the brain was recommended. The MRI revealed numerous white signal abnormalities in the periventricular and juxtacortical white matter consistent with demyelination and multiple sclerosis. The patient has now obtained consultation with two neurologists and various treatment options are presently being considered. Although a RAPD was not
Case 1 vs Normal Control The most important result is the profound difference in Constriction Amplitude in our patient between RE stimulation and LE stimulation. Constriction Amplitude is far more equal in the Normal Control “JS.”
Case 2: RAPDx Re A typical RAPD difference that is often referenced for normal patients is 0.0 to 0.3 log units (the difference between the RE and LE amplitude or latency responses). Our patient has a significantly reduced pupillary response when the RE was stimulated. Note the very large abnormal defect of
Normal Control “JS”
Case 1: Results from our Patient RAPDx combines the series of detailed, machine-vision observations of pupil responses to develop specific metrics to assess differential pupil responses The RAPDx signature is not human observable.
The RAPDx is a novel, objective test of pupillary function which requires no patient response and no examiner subjective assessment. Approximately 15,000 data points are obtained in about 1 minute. Our patient was evaluated with the RAPDx. Above, note the reduced constriction of the pupils with stimulation of the RE as contrasted with stimulation
case 1: Diopsys™ Nova-DN OU
Case 1: Diopsys™ Custom Test OU The VEPs above were obtained to smaller checks at high contrast (pattern reversal stimulus contains 64 x 64 checks). Under these conditions, the VEP P100 wave was delayed to 160 msec which is nearly a 50 msec difference when compared to the left eye. Such large delays
Case 1 DiopSyS™ Nova-DN OU In our 29 yr patient with blurred vision in her right eye, the VEPs are normal in amplitude but delayed in the right eye. Under high contrast conditions, the VEP P100 latency is delayed by 33 msec in the right eye when compared to the normal latency in
Exemplary normal VEPs with Diopsys™ Nova-ÐN
