Case #56 – The dawn of Pharmaco-Genetics for AMD

The dawn of Pharmaco-Genetics for AMD – Page 47 of 57

Case 5: Annidis MSI Red2 OS As in the previous case, is this early AMD? It certainly could be and gives the clinldan ammunition to strongly advIse the patient to stop smoking and to improve his diet. Genetic testing and supplemental nutriceuticals are a consideration.

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*Case 5: Annidis MSI OD The following images reveal early RPE epitheliopathy in a 38- year old Caucasian, heavy smoker, with light irides, a poor self-reported diet and a family history of AMD. He has no myopia or risk factors for other retinal disease or dystrophy.*Contributed by Dorothy Hitchmoth, OD

The dawn of Pharmaco-Genetics for AMD – Page 46 of 572023-01-31T21:30:12+00:00

The dawn of Pharmaco-Genetics for AMD – Page 45 of 57

Annidis MSI Red2 OS As in the previous case, is this early AMD? It certainly could be and gives the clinician ammunition to strongly advise the patient to stop smoking and to improve his diet. Genetic testing and supplemental nutriceuticals are a consideration.

The dawn of Pharmaco-Genetics for AMD – Page 45 of 572023-01-31T21:30:13+00:00

The dawn of Pharmaco-Genetics for AMD – Page 44 of 57

*Case 4: Annidis MSI OS These images reveal early RPE epitheliopathy in a 26- year old Caucasian, non-smoker, with light irides, a poor self-reported diet and a family history of AMD. He has no myopia or risk factors for other retinal disease or dystrophy.*Contributed by Dorothy Hitchmoth, OD

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Case 3: Topcon 3D OUI Image OU The PIL which has been previously shown in RR to correlate well with VA is normal in the right and somewhat attenuated in the left, especially above the PED. Hence, OCT, MSI and AF abnormalities all appear to reflect different abnormalities in AMD and related disorders.

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The dawn of Pharmaco-Genetics for AMD – Page 40 of 57

Case 3: Annidis MSI Infrared and Optos uwf AF OS In the left eye as well, there is a poor correlation between the melanin deposits and the AF findings. In any one case, it is unclear at present which technology is most sensitive to dysfunction.

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Case 3: Annidis MSI Infrared and Optos uwf AF OD The pigmentary changes noted on the MSI IR are most likely due to melanin clumping or stacking. The AF, which reflects abnormalities in the aging pigment lipofuscin (LF), appears normal. Note that melanin stacking can occur with normal LF as revealed with AF.

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