Case #6 – Vitreomacular Traction

Vitreomacular Traction Syndrome – page 25 of 26

References: J. Sebag 2005. Molecular Biology of Pharmacologic Vitreolysis. Trans Am Ophthalmol Soc;103:473-494 J. Sebag 2008. Vitreoschisis. Graefes Arch Clin Exp Ophthalmology: 246:329-332 J. Sebag, P. Gupta, R.R. Rosen, P. Garcia ,A.A. Sadun. 2007. Macular Holes and Macular Pucker: The Role of Vitreoschisis as Imaged by Optical Coherence Tomography/Scanning Laser Ophthalmology. Trans Am Ophthalmol

Vitreomacular Traction Syndrome – page 25 of 262020-06-15T15:35:48+00:00

Vitreomacular Traction Syndrome – page 24 of 26

Jerome Sherman, OD, FAAO Jerome Sherman, O.D., is perhaps optometry's most prolific writer, publishing over 650 clinical articles, research manuscripts, book chapters and two CDs. He is senior author of three books that were published in 2007, and has delivered over three thousand lectures both nationally and internationally. He has served as a

Vitreomacular Traction Syndrome – page 24 of 262020-06-15T15:44:19+00:00

Vitreomacular Traction Syndrome – page 23 of 26

The following is a list of links to the companies and contributors of Vitreomacular Traction Syndrome: https://www.lulu.com/content/hardcover-book/photoreceptor-integrity-line-as-revealed-by-spectral-domain-oct/5738467

Vitreomacular Traction Syndrome – page 23 of 262020-06-17T08:23:41+00:00

Vitreomacular Traction Syndrome – page 22 of 26

Histological Section as Compared to the OCT Image Although the photoreceptor integrity line, or the PIL (defined as the junction between the inner and outer segments) is barely visible in most histological sections, it is highly prominent in normal SD OCTs. The PIL, as shown above, should be continuous throughout the entire scan in

Vitreomacular Traction Syndrome – page 22 of 262020-10-21T07:12:36+00:00

Vitreomacular Traction Syndrome – page 21 of 26

A review of Pharmacologic Vitreolysis Pharmacologic vitreolysis is a promising new therapy to improve vitreoretinal surgery and, ultimately, prevent disease by mitigating the contribution of vitreous to retinopathy. Recent studies have demonstrated encouraging results with several enzymatic agents. Both plasmin and microplasmin are able to induce vitreous liquefaction and a posterior vitreous detachment with

Vitreomacular Traction Syndrome – page 21 of 262020-10-21T07:12:29+00:00

Vitreomacular Traction Syndrome – page 20 of 26

Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease15 as proposed by Jerry Sebag, MD Posterior vitreous detachment (PVD) is the consequence of changes in the macromolecular structure of gel vitreous that result in liquefaction, concurrent with alterations in the extracellular matrix at the vitreo-retinal interface that allow the posterior vitreous cortex to

Vitreomacular Traction Syndrome – page 20 of 262020-10-21T07:12:22+00:00

Vitreomacular Traction Syndrome – page 19 of 26

Comments and Conclusions (con't) In one study, no stage 1 lesions with posterior vitreous separation from the macula progressed to full thickness holes.4 In the same study, 47 out of 365 patients or 13% had a 4-year risk of developing a macular hole in the fellow eye.4 Most Stage 2 lesions enlarge and VA

Vitreomacular Traction Syndrome – page 19 of 262020-10-21T07:12:16+00:00

Vitreomacular Traction Syndrome – page 18 of 26

Comments and Conclusions The structure of the vitreous is more complicated than previously believed, and understanding its features may facilitate the mechanisms of vitreoretinal pathogenesis.4 The vitreous is a clear, semisolid gel containing hyaluronic acid interspersed in a framework of parallel collagen fibrils.13 Vitreomacular Traction (VMT) Syndrome results from persistent vitreoretinal adhesion in the

Vitreomacular Traction Syndrome – page 18 of 262020-10-21T07:12:11+00:00

Vitreomacular Traction Syndrome – page 17 of 26

Contemporary Classification of Macular Holes Stage 0 Oblique Vitreous Traction Stage 1 Macular Cyst Stage 2 Early full thickness macular hole Stage 3 Historical: Fully developed macular hole with complete posterior vitreous attachment, or Contemporary: Vitreous may be detached, often with vitreoschisis, where the outer layer is still attached.3 Stage 4 Fully developed

Vitreomacular Traction Syndrome – page 17 of 262020-10-21T07:12:06+00:00