Case #79: Type 3 Macular Neovascularization: a Unique Form of ARMD with a Possible Link to Stress

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About the Author Claire Goucher is a fourth-year student at SUNY College of Optometry where she will soon receive a dual degree of Doctor of Optometry and Master’s in Vision Science in May 2026. After graduation she will begin a residency program in Ocular Disease at the Providence

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Sources Hrishikesh, Vyawahare, and Shinde Pranaykumar. "Age-Related Macular Degeneration: Epidemiology, Pathophysiology, Diagnosis, and Treatment." Cureus 14.9 (2022).Centers for Disease Control and Prevention. "VEHSS Modeled Estimates: Age-Related Macular Degeneration (AMD)." Vision and Eye Health Surveillance System (VEHSS), National Center for Chronic Disease Prevention and Health Promotion, 15 May 2024, www.cdc.gov/vision-health-data/prevalence-estimates/amd-prevalence.htmlHobbs, Samuel D., Koushik

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Association Between ARMD and Stress Lavine et al. (2013) demonstrated that the β-adrenergic signaling pathway, which is activated during psychological stress, plays a direct role in promoting CNV. Using a mouse model of laser-induced CNV, they concluded that treatment with the beta blocker propranolol reduced CNV by 50%. Conversely, up-regulating

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The Role of Genetics in Treating ARMD Upon genetic analysis it was revealed that the patient was Genotype Group 2 (GTG2), a genetic risk classification in AMD research describing individuals who carry high-risk complement factor H (CFH) but carry no high-risk alleles at the ARMS2 locus. This genetic profile is clinically

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Treatment All patients with ARMD should be advised to quit smoking, wear UV protection when outdoors and adhere to healthy diet. Treatment with AREDS-2 vitamins taken twice daily should be initiated if ARMD progresses past the early stage.5 Before antiVEGF treatments were available, wet AMD was treated with thermal laser photocoagulation,

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