Drusen: Clinical Features
Three types of drusen:
Hard drusen
(cuticular or infiltrative):
• Small, Yellow-White deposits of lipid-rich material
• Typically 50-75 µm in size
• Location: between RPE and Bruch’s
Subretinal drusenoid deposits*:
• Drusenoid-material, similar to drusen in appearance
• Size 50-75 µm
• Location: subretinal between RPE and PIL
Soft drusen:
• Large, pale-yellow or yellow-white lipid-rich deposits with softer borders
• Size: 63-1,000 µm in diameter
• Location: between RPE and basement membrane
Note: many drusen are smaller than 30 microns and hence are invisible to ophthalmoscopy but not to SD-OCT.
*Areas of geographic atrophy and hard drusen are also present in the fundus image.