Early Detection of Stargardt Disease with OCT and AF – Page 26 of 30

Comments and Conclusions

• The initial clinical finding of early Stargardts Disease (SD) may be the abnormal ELM as exhibited in both eyes of each daughter.⁵
• The hyper-reflective ELM with OCT may represent degeneration of the cone and rod nuclei within the outer nuclear layer as hypothesized on pages 21-23.
• Oral treatment to reduce the accumulation of toxic Vitamin A dimers is one of several promising interventions.
• The ELM as a biomarker for early SD may be useful to monitor the efficacy of treatment.
• Early Dx of SD followed by various interventions may lead to a better outcome.