Mac Degen in 2010 – Page 57 of 62

Delcourt et. al. (POLA Study) (Inv. Ophth. and Visual Science: 2006)
• Patients with high plasma levels of Zeaxanthin had a 93% reduction of AMD.
Gale et. al. (Ophthalmology and Visual Science: 2003)
• Low levels of plasma Zeaxanthin correlated with significantly higher AMD risk. Tan et. al. (Blue Mountain Study) (American Academy of Ophthalmology: 2008)
• Higher dietary intake of zeaxanthin and lutein reduced AMD risk by 65%.
AREDS Report 22 (Archives of Ophthalmology: 2007)
• Participants with highest intake of zeaxanthin & lutein were less likely to have advanced AMD. O’Connell & Nolan et. al (Am. J. Of Clin. Nutrition 2008, Sci. Direct & IOVS 06/07)
• Low MPOD correlates with key AMD risk factors such as age, smoking, and AMD family history. Connolly, Beatty, Nolan et. al (Current Eye Research, vol 35 no. 4 April, 2010) Augmentation Of Macular Pigment Following Supplement Of All Three Carotenoids: An Exploratory Study
Dimitrov et al. (Investigative Ophthalmology and Visual Science, January 2008 Vol 49 No. 1) Measuring Rod and Cone Dynamics in Age-Related Maculopathy
Newsome and Negreiro (Current Eye Research vol 34 no. 2 February, 2009) Reproducible Measurement of Macular Light Recovery Time Using a Novel Device Can Indicate the Presence and Worsening of Macular Diseases