Comments and Conclusions
- The structure of the vitreous is more complicated than previously believed, and understanding its features may facilitate the mechanisms of vitreoretinal pathogenesis.4
- The vitreous is a clear, semisolid gel containing hyaluronic acid interspersed in a framework of parallel collagen fibrils.13
- Vitreomacular Traction (VMT) Syndrome results from persistent vitreoretinal adhesion in the setting of partial posterior vitreous detachment (PVD).5
- PVD occurs in upwards of two out of three individuals over the age of 65, and is defined as the separation of the dense outer layer of type II collagen fibrils of vitreous, known as the posterior vitreous cortex, from the internal lamina of the retina.4
- Eyes with perifoveal vitreous detachment (PVD) appear to be at especially high risk for developing secondary macular hole. Several lines of evidence suggest that PVD association with macular holes is causal rather than coincidental.9
- The different stages of idiopathic macular holes have outcomes that vary so management of idiopathic macular holes can be based on their stage at presentation.6
- One third of stage 1 macula holes with posterior vitreous attachment to the macula develop a full thickness macula hole.9