Subretinal Drusenoid Deposits (SDDs) in AMD

  • SDDs are strongly correlated with advanced AMD
    • Geographic atrophy (GA) > Choroidal neovascularization (CNV) > intermediate AMD  > early AMD1,2
  • SDDs are poorly detected on clinical exam and color fundus photography
    • SDDs are more common than previously reported and are underappreciated in clinical settings2
  • SDD identification should employ multimodal imaging
  • Recommended non-invasive imaging includes:2,3
    • SD-OCT – utilization of BScans, en face analysis, and SLO functions
    • Near-infrared reflectivity (NIR)
    • Fundus autofluoresence (FAF)
    • Color fundus photography (CFP)
  • Dark adaptation is severely impaired in the presence of SDDs3