Comments and Conclusions
• CSC is one of the 10 most common diseases of the posterior segment of the eye and a frequent cause of mild to moderate visual impairment.²
• Optical coherence tomography (OCT) has provided a better understanding of the mechanism in CSC, especially the abnormalities of the RPE layer.³,⁴
• OCT in conjunction with fluorescein angiography (FA) has detected RPE abnormalities such as a PED at the leakage points of FA. One such study showed these findings in 26 of 27 eyes, suggesting that there might be a defect in the RPE layer that allows passage of fluid from the sub-RPE to the subretinal area.³
• Serous detachment of the neurosensory retina often resolves spontaneously. After 3 months without resolution of acute CSC or chronic CSC, treatment should be considered.²
• Resolution of serous detachment in acute CSC can usually be achieved by focal photocoagulation of leaking RPE lesions.²,³
• Photodynamic therapy with verteporfin has beneficial effects in treating patients with chronic CSC by reducing fluid leakage, subretinal fluid accumulation, and serous detachment with resultant improvement of vision.⁵,⁶
• Studies have shown that corticosteroid use can lead to an acute onset of symptoms and clinical manifestation of CSC. In one such study, all patients who used corticosteroids before the onset of CSC experienced spontaneous resolution of their detachments when the steroid treatment was discontinued.⁷