Congenital Hypertrophy of the RPE – Page 21 of 44

Familial adenomatous polyposis (FAP) has been linked to the appearance of CHRPE-like lesions in the retina. These CHRPE-like lesions are RPE abnormalities that occur bilaterally and have some degree of variability in size and shape.¹ There are usually four or more lesions present (not grouped like “bear track” lesions) and they may show depigmentation in a lacunar or tail-like fashion along with peripheral RPE stippling.¹ If surgical removal of the colorectal polyps is not performed on patients with FAP, it can lead to the development of colon cancer and can often be fatal.⁸