Congenital Hypertrophy of the RPE – Page 24 of 44

Histopathological features of isolated CHRPE include hypertrophic RPE cells engorged with melanosomes and minimal or absent lipofuscin in pigmented areas.¹ The depigmented areas within the lesion where pigment granules are very sparse, known as lacunae, correspond to atrophic RPE cells with few melanosomes and thickening of Bruch’s membrane.^1,2 In this instance, the lacunae appears as a “gingerbread man”.