Case 2: Zeiss VISUCAM Color Fundus Camera Image OD March 2007
Ninety five percent of patients affected by LHON have one of three primary point mutations on the mitochondrial gene which codes for Complex I of the oxidative phosphorylation pathway. These three primary mutations occur at positions 11778/ND4, 3460/ND1 and 14484/ND6 of the mitochondrial DNA. Visual prognosis is worst in patients with the 11778 mutation and best with the 14484 mutation.
