Ganglion Cell Complex (GCC) Background Information
Excerpt from “Direct Ganglion Cell Assessment with the RTVue by Optovue: The Ganglion Cell Complex Analysis” by Mike Sinai, Ph.D.
Retinal ganglion cells encompass three layers in the retina:
- The retinal nerve fiber layer (RNFL) is made up of the ganglion cell axons
- The ganglion cell layer (GCL) is made up of the ganglion cell bodies
- The inner-plexiform layer (IPL) is made up of the ganglion cell dendrites.
- All three layers, collectively known as the ganglion cell complex (GCC), become thinner as the ganglion cells die.
- The RTVue directly measures the thickness of these three layers and provides a unique analysis of the percent loss of these layers compared to an extensive normative database.
- The results are presented as significant loss from normal (Significance) in order to aid in the clinical interpretation.