Case #58 – Neurofibromatosis Type 1

Examples of Lisch nodules of the iris (top image) and Optos California® fundus images (bottom two images) of optic nerve atrophy OU secondary to optic nerve glioma in Patient #1 Various reports1-7 have highlighted a potential new clinical feature of NF1. Here we present two patients with this clinical

NF1, CAN YOU “SPOT” THE CLINICAL FEATURE?   Introduction: Neurofibromatosis Type 1 (NF1) is a genetic condition which there is dysfunction of the neurofibromin protein which plays a role in tumor suppression and therefore causes multiple tumors of neural crest origin.1Two or more of the following characteristics are needed to diagnose NF1: six or