Case #65 – Subretinal Drusenoid Deposits (SDDs) in AMD

ReferencesFinger RP, Chong E, McGuinness MB, et al. Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study. Ophthalmology. 2016;123(3):599–608.Chen, L, Messinger, JD, Zhang, Y, Spaide, RF, Freund, KB, & Curcio, CA. (2020). Subretinal drusenoid deposit in age-related macular degeneration: histologic insights into initiation, progression to atrophy, and imaging. Retina

Dr. Amanda Legge graduated from PCO at Salus University in 2012. She obtained an advanced studies in retina certification during her studies at PCO with retina-centric internships.Her retina interests include AMD, inherited retina disease, and diabetic and hypertensive retinopathy. She is also a primary eyecare provider to all ages.With regards to AMD she

Final CommentsSDDs are underdiagnosed and their clinical significance is often under-appreciated in clinical carePresence of SDDs cause severe impairment of dark adaptationPresence of SDDs in AMD significantly increases risk of progression to advanced AMD, both geographic atrophy and choroidal neovascularizationSDDs are not easily visible during funduscopySDDs should be actively ruled out on every patient

Macular SDD Subtypesmay have clinical significance in progression Ribbon SDDs Eyes with ribbon subtype have a 4.3 fold increased risk in developing GA24 Photoreceptors are disrupted in areas surrounding ribbon SDDs as well as in the area of SDDs themselves25 Dot SDDs Eyes with dot subtype have a 2.5 fold

Macular SDD Subtypes18  

Macular SDD Subtypes18

Case 2: Progression January 2024 

Case 2: Progression October 2023 

Case 2: Progression June 2023