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Case 2: Zeiss VISUCAM Color Fundus Camera Image OD March 2007 Ninety five percent of patients affected by LHON have one of three primary point mutations on the mitochondrial gene which codes for Complex I of the oxidative phosphorylation pathway. These three primary mutations occur at positions 11778/ND4, 3460/ND1 and 14484/ND6 of the
Case 2: Topcon Color Fundus & Zeiss GDx OD September 2004 Case 2: A 15-year-old Filipino male with an established family history of LHON mt 11778 was followed closely prior to and during the acute phase of LHON with GDx scanning laser polarimetry, Stratus optical coherence tomography, Humphrey automated perimetry (Carl Zeiss Meditec,
Case 1: maia™ Time Change Analysis OS In contrast, sensitivity ot various points tested in the lett eye improved slightly, but none reached statistical significance. Note since the drug has only been tested on five people with LHON, limited information about how long the drug takes to work is available. The consensus among
Case 1: maia™ Time Change Analysis OD The maia™ was repeated 24 days after the initial visit (two weeks after the initiation of treatment). Note the sensitivity of many points decreased significantly corresponding to the red dots in the right eye. The numbers correspond to the change in dB sensitivity over time. The white
All the previous findings support the diagnosis of acute onset LHON. Discussion of a new and promising treatment was discussed in detail. I recommended that the patient take the first plane the next morning to Los Angeles for possible treatment with Edison Pharmaceutical's new drug EPI 743. All the data, including the previous genetic
Case 1: iVue iHealthCheck OU The GCC (which is composed of the RNFL, the ganglion cell layer and the inner plexiform layer) is represented by the "green donut" above and appears normal and equal in each eye. The table above reveals only very minor differences between all GCC measurements. This suggests that the
Case 1: maia™ Sensitivity Map OU Although the BCVA was 20/25- OD and 20/20 OS, the maia™ visual field above demonstrates a dramatic difference in the central visual field sensitivity between the two eyes.
Case 1: maia™ Sensitivity Map & 30-2 Visual Field Comparison OS Virtually all patients with the LHON mt 11778 progress to profound vision loss within weeks to months once vision loss is initially experienced. The second eye become affected within just several months and final VA is typically the same in each
Case 1: maia™ Fixation Plot & Graph OS As in the OD, fixation is quite stable in the OS.
Case 1: maia™ Sensitivity Map & Threshold Histogram OD Four points have a mildly reduced sensitivity to 23 dB in the OS.
