Case #55 – Early Detection of Stargardt Disease with OCT and AF

Early Detection of Stargardt Disease with OCT and AF – Page 9 of 30

Case 2 (5 yo daughter): Topcon Fundus Photos OD and OS Case 2 (5 yo daughter): Above are the fundus photos of the five year old daughter. She had no symptoms but best corrected VA 20/25+ in each eye. The images above reveal normal white glistening reflections off the internal limiting membrane in each eye.

Early Detection of Stargardt Disease with OCT and AF – Page 9 of 302023-02-02T20:23:55+00:00

Early Detection of Stargardt Disease with OCT and AF – Page 8 of 30

Case 1 (8 yo son): Optomap® FAF Image OD and OS Both the AF images and the OCTs reveal marked abnormalities in the outer retina of both eyes. AF-hyper and laterhypo findings suggest a primary abnormality of the RPE and secondary involvement of the overlying photoreceptors.Stargardt’s disease with fundus

Early Detection of Stargardt Disease with OCT and AF – Page 8 of 302023-02-02T20:23:55+00:00

Early Detection of Stargardt Disease with OCT and AF – Page 7 of 30

Case 1(8 yo son) : Topcon 3D OCT OS The five high resolution horizontal OCT scans in the left eye are very similar to the corresponding scans in the right eye. Although the fundus photo displays only mild abnormalities, the SD OCTs are quite abnormal.

Early Detection of Stargardt Disease with OCT and AF – Page 7 of 302023-02-02T20:23:56+00:00

Early Detection of Stargardt Disease with OCT and AF – Page 4 of 30

Case 1(8 yo son) : Topcon 3D OCT OD  The son's SD OCT and fundus photo above are compared to those of a normal below. Note the macula thinning in the son's OCT. Also note the absence of the all important PIL (photoreceptor integrity line RR#2). It appears that the son's outer retina is

Early Detection of Stargardt Disease with OCT and AF – Page 4 of 302023-02-02T20:23:56+00:00

Early Detection of Stargardt Disease with OCT and AF – Page 3 of 30

Case 1 (8 yo son): Fundus Photography KEY: Color Optomap Red Separation Green Separation Auto Fluorescence A comparison of standard fundus photos to AF images clearly reveals unmistakable abnormalities in the AF images only. Note that the small hyper AF lesions are often not round and many are fish tail or pisciform

Early Detection of Stargardt Disease with OCT and AF – Page 3 of 302023-02-02T20:23:56+00:00

Early Detection of Stargardt Disease with OCT and AF – Page 2 of 30

Case 1. (8 yo son) : Optomap® FAF Image OD and OS Fundus auto-fluorescent (FAF or AF) photos revealed a central hypo-AF oval in each eye. Encircling this was a large hyper-AF zone that extended beyond the arcades. Even brighter hyper-AF spots or flecks were also observed, most marked around the disc and

Early Detection of Stargardt Disease with OCT and AF – Page 2 of 302023-02-02T20:23:57+00:00

Early Detection of Stargardt Disease with OCT and AF – Page 1 of 30

Case 1 (8 yo son) : Topcon Fundus Photos OD and OS Case 1(8 yo son): A mother presented with her 3 children on referral. Although her 4 and 5 year old daughters had no visual symptoms and were never evaluated, her 8 yo son complained of progressive reduction of vision at distance and

Early Detection of Stargardt Disease with OCT and AF – Page 1 of 302023-02-02T20:23:57+00:00